glutathione reductase is an essential enzyme in plants that contributes to cellular redox homeostasis. Its activity is vital for maintaining the balance between oxidized and reduced glutathione and is also responsible for the regeneration of reduced glutathione (GSH) from its oxidized form, glutathione disulfide (GSSG). The primary function of glutathione reductase is to maintain the cellular pool of reduced glutathione, which is an essential antioxidant molecule.  The enzyme is found in different subcellular compartments, including the cytosol, chloroplasts, mitochondria, and peroxisomes, reflecting its diverse functions within the plant cell. The activity of glutathione reductase in plants can vary depending on various factors such as developmental stage, tissue type, and environmental conditions. The present review gives a comprehensive overview of the importance of this enzyme.