The antimicrobial activity of the Indian botanical medicinal plants Azadirachta indica and Aloe vera was investigated using the agar disc diffusion method against clinical bacteria such as Escherichia coli and Staphylococcus aureus, as well as phytopathogenic bacteria such as Xanthomonas vesicatori and Xanthomonas citri. Escheria coli is used to test the antimicrobial activity of Azadirachta indica (Neem), Aloe vera, and Garlic against common endodontic pathogens such as Staphylococcus mutans, Enterococcus faecalis, and Staphylococcus aureus. The goal of this research is to look at the antibacterial characteristics of plants that are often utilised in traditional medicine.Plant-derived products have the ability to limit microbial development in a variety of situations, including disease therapy. Aloe vera is a well-known medical plant that has a variety of uses. It is naturally made up of a variety of beneficial substances that can be used to cure a variety of ailments. Because of its antibacterial, antimalarial, and antifungal qualities, neem is considered a medicinal plant. Its anti-fungal and anti-bacterial properties help to keep harmful bacteria and fungi at bay, protecting the skin and preventing skin diseases. The antibacterial activity of natural plant extracts with various solvents was tested using the disc diffusion method in this study.

    KEYWORDS:  

   Plants extract(Neem and Aloe vera),disc diffusion method,solvents,clinical disease causing bacteria, antimicrobial assay.