With the advancement of days, patients with diabetes become household. Many synthetic, semisynthetic, and pharmacological agents have been introduced but fail to neutralize. Hence, this review aims to outline diabetic inducing agent and their pharmacology for new drug screening. Different search engines such as google scholar, PubMed, ScienceDirect, and Elsevier were used to do this review. Our study reports the pharmacology of diabetic inducing agents alloxan monohydrate and streptozotocin. This review will help researchers to choose the right chemicals based on methodology.

Keywords: Alloxan, chemical-induced diabetes, hyperglycemia, streptozotocin,