The present study concerns the formulation and evaluation of floating tablets of Levofloxacin, which enhance the gastric residence time and drug bioavailability after oral administration. Levofloxacin is a synthetic chemotherapeutic agent used to treat bacterial infections. Formulations were prepared using various polymers like Xanthan Gum, Guar Gum and Karaya Gum by wet granulation technique. Various formulation batches were evaluated for various parameters like weight variation, thickness, hardness, friability, floating lag time, content uniformity and in-vitro drug release. The study has revealed that the release rate from floating tablets depends on type and concentration of polymer. The formulations F3 prepared with Xanthan gum (35%) showed higher drug release rate i.e. 98.16% ± 0.9 over an extended period of 12 hours. Hence F3 was considered as best formulations. It is concluded that Levofloxacin floating tablets can be formulated with Xanthan gum, Gaur gum and Karaya gum polymers to achieve gastro retention and controlled release by employing wet granulation technique.

KEYWORDS: Levofloxacin, Gastro retentive, Floating tablet, Guar gum, Xanthan gum and Karaya gum