Organophosphates(OPs) are the most commonly used pesticides in the world. In an agrarian country like India, OPs are the most common cause of suicidal deaths due to pesticides. This observational study was conducted to assess the utility of estimation of serum amylase in the assessment of clinical outcomes in OP poisoning cases. The study aimed at finding an association between serum amylase and the severity of OP poisoning based on Peradeniya organophosphorus poisoning (POP) Scoring Scale and usefulness of serum amylase in assessing the prognosis in terms of ventilator requirement, duration of intensive care

Unit (ICU) stay and mortality in OP Poisoning cases.

Materials and Methods: The study was conducted after institutional ethical clearance in hospitals associated with a tertiary health care center affiliated to a medical college in south India. 90 OP poison cases were recruited in this longitudinal study over a period of two years. Patients were clinically examined for a POP score;

blood was analyzed for serum amylase levels on the first day of admission and patients were followed up till death or discharge from the hospital.

Results: 46.7% of the study population had elevated serum amylase levels. Serum amylase showed a significant (p<0.0001)positive correlation with the severity of OP Poison based on POP Scoring System, increased duration of ICU Stay, ventilator requirement, and mortality.

Conclusion: Serum amylase an easily available laboratory investigation can be cost effective in the assessment of clinical outcomes in OP Poisoning and aid in the early prompt and vigorous management of OP Poisoning cases for a better outcome.

Keywords: clinical outcome in organophosphate poisoning, heart rate, intensive care unit stay, pupillary dilatation, respiratory rate, ventilator support