The aim of this study is to investigate the Antidiabetic activity of leaves extract of Gliricidia sepium (EEGSL) in Alloxan-induced diabetic rats. The animals were grouped as control (distilled water and Glibenclamide) and experimental (250, 333, and 500 mg/kg body weight). Type 2 DM was induced by a single intraperitoneal injection of alloxan at 120 mg/kg body weight. The blood sugar levels were estimated by employing the glucose kit from Aspen diagnostics and measured in Semi auto analyzer. The lipid profile and histopathological studies of experimental animal were studied. The results of three dose levels and Standard treatment showed downstream levels from hyperglycemic condition on blood glucose level (P<0.01) and restored the normal functioning of the various organ functions and brought the lipid levels from hyperlipidemia due to diabetes. The extract has shown notable therapeutic effects which can be seen clearly in regeneration capacities histopathological changes of the pancreas in alloxan-induced diabetes.

Keywords: Alloxan, Antidiabetic, Flavonoids, Tannins, Gliricidia sepium, Glibenclamide