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Elevated maternal serum iron concentrations and decreased platelet count in women with pregnancy induced hypertension: A systematic review of observational studies.

. Bhaktraj Singh1, Roopa Satyanarayan Basutkar* First Author: 1Bhaktraj Singh, Intern student, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris-643001, Tamil Nadu, India Correspondence Author: Roopa Satyanarayan B


Abstract

Increase in level of maternal serum iron and decreased platelet count will damage of the vascular endothelium and increase the level of blood pressure. From Cochrane CENTRAL, PubMed, Google scholar and Scopus, eight observational studies were identified. Joanna Briggs Institute (JBI) data extraction form and Quality Assessment Tool (NHLBI) was used. In the study conducted by Rayman MP et al and Gutirerrez-Aguirre CH et al there was 1.7-fold increase in serum iron in preeclampsia group. In the studies conducted by Alkholy EA et al, Shetty J et al and Damani Z et al revealed the platelet count was significantly lower in pregnancy induced hypertension group. Based on the findings, this review has highlighted that pregnancy induced hypertension is significantly associated with increased in maternal serum iron concentrations and the reduced platelet indices.  A protocol to be established during the antenatal care to check the serum iron concentrations and platelet indices.           

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