Marburg and Ebola viruses are filamentous filoviruses that are distinct from each other but that cause clinically similar diseases characterized by hemorrhagic fevers and capillary leakage. Infections with the Ebola virus are significantly more virulent than infections with the Marburg virus. There are nonspecific initial clinical signs of these diseases and they can resemble other endemic pathogens. This makes it difficult to have a confident diagnosis based on clinical symptoms alone. Present molecular tests are focused on the identification of virus material in the blood to classify infections with high-consequence viruses such as the Ebola virus and the Marburg virus. These viruses do not experience extensive early replication in the blood and replicate in organs such as the liver and spleen instead. Therefore, after significant replication has already occurred in certain tissues, the virus starts to accumulate in the blood, rendering viremia an indication of infection only after initial stages have been identified. The function of the immune cell molecular mechanism against the Marburg virus and Ebola virus remains vice versa. In addition, this would help us figure out the difference between the Marburg virus and the Ebola virus. However, the researchers were also puzzled between the Marburg virus and the Ebola virus with the concept of the molecular mechanism of immune cells. We would like to summarise the exact function of the molecular mechanism of immune cells in the Marburg virus in this review.

keywords: Marburg virus infection, Natural killer cells, Monocyte gate, MHC class II molecules, MHC class I molecules.