The existing research work is to examine the photoinduced dye degradation behavior of zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs). The plant extract and nitrate dihydrate salt of zinc and copper was used to synthesize ZnO and CuO NPs. The extract was of neem plant and acts as a stabilizing, capping and reducing agent. The synthesized NPs are analyzed using UV-Visible technique and the degradation efficiency of both NPs under direct sunlight was also studied. The maximum light absorbed by the NPs at specific wavelength was revealed using UV-Visible analyzer i.e., 350 and 222 nm for ZnO and CuO NPs, respectively. The degradation behavior of NPs was observed against dyes known as methylene blue (MB) and methyl orange (MO). The ZnO NPs degraded dyes to the extent of MB (93.93%) and MO (86.36%), while CuO degradation behavior was found to be MB (94.5%) and MO (93.45%). Overall, both of the NPs showed greater degradation efficiency against MB as compared to MO because MO forms stronger bonds with photocatalysts and is resistive to breakdown. The reusability study of NPs was also performed revealing that both, ZnO and CuO, NPs could be used for dye degradation up to three cycles even after every cycle NPs efficiency is reducing.