Amnesia is characterized by an inability of a person that can no longer memorize or recall information that is stored in memory. Despite the fact that effective therapies for age-related cognitive decline and neurodegenerative illness are urgently needed. Walnuts (Juglan regia) seem to be abundant in phyto-chemicals, notably poly-unsaturated fatty acids, and may provide beneficial wellbeing effects, particularly to the brain. An alkaloid hyocine; having an anticholinergic activity which also suppresses the muscarinic responses of acetylcholine on post-ganglionic para-sympathetic nuro effector regions in the central nervous system, smooth muscle, and some secretary glands. Two different test group units and one control group of animals were created at random. One test group treated with buscopan while the second test group administered buscopan+walnuts. Cognitive functions were evaluated using the Morris-water-maze while brain acetylcholine levels were also estimated. Antioxidant properties were evaluated by estimating malondialdehyde levels in brain. Present study showed that administration of buscopan impaired memory functions observed in increase in latency time and decrease in brain acetylcholine levels while these effects were significantly attenuated by administration of walnuts. Increased levels of malondialdehyde due to buscopan also decreased significantly with coadministration of walnut in brain.

Key Words: Amnesia, Walnut, Memory, Acetylcholine, Malondialdehyde