Cryptosporidiosis, a parasitic contamination brought about by Cryptosporidium species, represents a critical wellbeing challenge, especially for vulnerable compromised people, like those living with HIV. The worldwide HIV pandemic has worked with the spread of sharp disease, with Cryptosporidiosis arising as a main source of causing diarrhea and serious sickness among HIV positive people. This review centers around the study of disease transmission and treatment of Cryptosporidiosis in individuals living with HIV (PLHIV). The pervasiveness of Cryptosporidiosis shifts generally from zero to hundred percent relying upon geological district, with higher rates seen in regions with restricted admittance to Antiretroviral Treatment (ART). Transmission of Cryptosporidiosis happens through immediate and round about contact, water conceived pathway and less usually sexual contact and medical care settings. Resistant compromised patients Likely who are with low CD4+ T lymphocyte numbers (<100cells/mm3), are more defenseless against persevering Cryptosporidiosis which can bring about delayed looseness of the bowels, lack of hydration, ailing health and increment mortality. Determination is much of the time affirmed through sub-atomic examine and microscopy and routine testing for Cryptosporidiosis isn't broad in numerous localities. Treatment stays testing as no all-around viable chemotherapeutic specialist exist. Nitazoxanide, the main FDA supported drug for Cryptosporidiosis shows restricted effectiveness in safe compromised people. Workmanship has demonstrated compelling in supporting resistant capability consequently helping control the contamination in a roundabout way. The continuous fight against Cryptosporidiosis in PLHIV highlights the significance of further developing admittance to ART upgrading demonstrative ability and growing more compelling medicines. This Review features the requirement for proceed with examination and general wellbeing mediation to address the worldwide weight of Cryptosporidiosis, especially in assets restricted settings where sicknesses stay generally pervasive.

Keywords- Cryptosporidiosis, HIV, Antiretroviral Treatment (ART), Immune-compromised patients, Nitazoxanide, Epidemiology