Background: The method which can help to manage problem by modifying thinking behavior and ways among patients is termed as cognitive behavioral therapy. Primarily, it does not remove the problem but help in managing the problems in positive way. It was first introduced as ago as 1950, however, was lacking research-based evidence on it.

Objective: The objective of this study was to determine effectiveness of cognitive behavioral therapy on pain, mobility and disability in patients with osteoarthritis.

Methods: This was randomized clinical trial conducted on 50 patients, 25 in each of cognitive behavior group and control group. The outcome such as symptoms, mobility, stiffness, function and quality of life were measured by Knee Injury and Osteoarthritis Outcome Scale. The data was analyzed by Statistical Package for Social Sciences (20.0). The demographics were analyzed as Number distribution for categorical variables and mean/ standard deviation for continuous variables. Independent samples t test was used to compare mean of test variables at before and after treatment.

Results: Main results showed a significant better measure for patients taking cognitive behavior therapy with routine for knee osteoarthritis such as shown by mean difference and p value as walk time 3.52 minutes (p value 0.008), symptoms 2.12 (p value 0.000), stiffness 0.88 (p value 0.000), pain 4.04 (p value 0.000), functions 7.400 (0.000), sports 1.04 (0.056), quality of life 1.12 (0.04) and KOOS percentage 9.87 (0.000).

Conclusion: The study concluded that cognitive behavior therapy had remarkable role in improving pain, mobility and disability in patients with osteoarthritis when combined with routine physical therapy.

Keywords: Cognitive Behavioral Therapy, Osteoarthritis, Physical Therapy, Knee Joint