Trillions of microorganisms, mainly bacteria, live in the gut microbiome and are essential to the host's physiological and metabolic health. In this regard, research has revealed a direct relationship between the gut microbiota and the development, course, and management of cardiovascular diseases (CVDs). Dietary habits influence the gut microbiota through various metabolic pathways. Eating a balanced diet supports gut microbiota whereas high consumption of red meat and fats leads to unfavorable microbial shift which can produce harmful metabolites. Consequently, these metabolic products can negatively influence the different body cells and lead to gut microbiota-driven heart failure, hypertension, atherosclerosis, myocardial infarction, myocardial fibrosis, and coronary artery disease (CAD). To improve both the development of treatments and the prevention of CVDs, this review primarily focuses on investigating the role of gut microbiota-associated metabolites and their therapeutic potential in CVDs. It's quite possible that shortly, gut microorganisms used for the clinical treatments of CVDs.

Keywords

Gut microbiota, Gut-Heart axis, Dysbiosis, Metabolites, Cardiovascular Diseases, atherosclerosis, hypertension