The emergence and dissemination of highly resistant microorganisms is one of the major issues faced by public health today. Infections brought on by bacteria which are resistant to all available antimicrobials in the therapeutic arsenal have already started to appear. In stark contrast to the demand, there is a dearth of new innovative techniques to treat microbial infections that pose a serious concern due to resistant microorganisms. Numerous advanced techniques are being researched, with bacteriophage therapy as one of the possibilities. Bacteriophages represent an alternative option to combat these extensive drug-resistant microbes, because they are narrow-spectrum and can be employed to specifically kill target bacteria without upsetting the entire community structure through off-target impacts. As the number of phage-based research facilities increases globally, the encouragement of well-designed clinical trial growth, standardization of phage cocktail manufacture and storage, and advancement of international collaboration will become more crucial. The main aim of this review is to discuss the history, advantages, limitations, and present state of bacteriophage research and its applications to fight against antibiotic resistance, with an emphasis on ongoing clinical trials and animal models of phage therapy administration. The purpose is to discuss bacteriophages as an alternative option to treat infectious pathogens that have developed resistance to all or most of the available antimicrobial drugs.