Gut microbiota profile is an essential part of the human body physiology and is associated with the high carriage of ARGs. This review focuses on the intricate relationship between gut microbiome and antibiotic resistant bacteria with special reference to the several ways that bacteria get antibiotic resistance genes, such as horizontal gene transfer and mobile genetic elements. Antibiotics come into bacteria and alter the composition and structure of microbiota by inducing dysbiosis and creating a persistent resistome that perpetuates the occurrence of resistance. On these lines, several approaches are proposed to overcome this problem, and they include the administration of probiotics and prebiotics to rebalance the beneficial micro flora, the control of antibiotics usage, the application of newer concepts such as phage therapy, FMT and alterations in the diet pattern. Further, strategies such as innovation of new antibiotics and additional agents capable of counteracting the resistance mechanisms also holds some possible solutions. The review underscores a call for heightened collaboration of various branches of medicine and academia as well as further research to curb the emerging menace of antibiotic resistance and to maintain the effectiveness of antibiotics in the treatment of bacterial infections