Objectives: This study examines the levels of psychological stress among caregivers of chronic kidney failure patients at Ramallah Government Hospital, with a focus on how gender, age, and place of residence influence stress levels. 

Methodology: A descriptive approach was employed, using a convenience sample of 75 caregivers. The study utilized a 27-item Psychological Stress Scale, which was validated and demonstrated high reliability (Cronbach's Alpha = 0.92). 

Results: The findings revealed significant differences in psychological stress levels based on gender, age, and place of residence. Female caregivers reported higher levels of general psychological, behavioral-physiological, and emotional stress compared to male caregivers. Additionally, older caregivers and those living in rural areas experienced higher stress levels compared to their younger and urban counterparts. 

Conclusions: The study underscores the need for psychological support programs tailored to the specific needs of caregivers, particularly females, older individuals, and those living in rural areas. These programs should address the distinct stressors faced by these groups to improve their overall well-being. 

Keywords: psychological stress, caregivers, chronic kidney failure