Di thiocarbamates are adaptable mono-anionic chelating ligands that combine with transition and main group elements to form stable complexes. They can be readily synthesized from primary or secondary amines and exhibit good solubility in water and organic solvents. They are electrically tunable and lipophilic by selecting various substituents. Di-thiocarbamates' soft and hard thioureide resonance forms can stabilize metals in a range of oxidation states. Many thiocarbamate complexes have been prepared, including Zn (II), Ni (II), and Cu (II).These complexes were created by reacting step-by-step. First, at -5 ^oC, aniline and CS2 were stirred for ten minutes. Metal salt was added in the second step.The necessary product was obtained after some stirring. The final product was dried to determine its yield. Various complexes produced varying yields. 167 compound had the highest yield, 95%. The complexes were characterized using UV-Vis spectroscopy and NMR (1 H and 13 C). Tests for thrombolysis and hemolysis were used to examine the complexes' antimicrobial activity. The structures of the Zn (II) and Cu(II) complexes were found to be mononuclear and dinuclear, respectively.In tests against cancer cells, morphine di-thiocarbamate proved to be more effective than parthenolide. The copper (II) complex is superior to parthenolide.

Keyword: Chelating, di-thiocarbamates, hemolysis, parthenolide, thrombolysis, ligand, metal complexes, thrombolysis.