A class of chemical compounds known as Diclofenac has the general formula: C₁₄H₁₁Cl₂NO₂. Nanoparticles based diclofenac are special chemical compounds synthesized from the reaction of nanoparticles with diclofenac derivatives. The most common method for creating nanoparticles based diclofenac derivatives involves converting of diclofenac to Hydrazide and oxadiazole thiol and finally reacting with Zn and Mg nanoparticles in various chemical solvents like butanol as ethanol. Diclofenac are used for a variety of things, including medications, the production of polymers and adhesives, industries, and many other things. Acid-catalyzed cyclization of N-(2, 6-dichlorophenyl)-α-(methylsulfinyl) acetanilide or α-chloro-N-(2, 6-dichlorophenyl)-α-(methylthio) acetanilide resulted in desulfurization and hydrolysis of the resulting 1-(2, 6-dichlorophenyl)-3-(methylthio) oxindole, which was used to make diclofenac, a powerful anti-inflammatory drug. Diclofenac has long been used to treat antibacterial infections.. For a long time, bacterial infections have been treated using medications based on nanoparticles based diclofenac derivatives. The product was cleaned by recrystallization with ethanol after being separated by filtering. The products 119-120 obtained 70-80% yield. Antibacterial infections have traditionally been treated with diclofenac. For a long time, bacterial infections have been treated using medications based on nanocomposite based diclofenac