Objective:

To assess the efficacy of Tamsulosin versus Silodosin in Medical Expulsion Therapy for Distal Ureteric Stones.

Materials and Method:

70 patients were enrolled in this prospective study. Patients presenting with ureteric colic, diagnosed with unilateral distal ureteric stone less than or equal to 7 mm were included in the study from an age range of 18 to 60 years. Patients with multiple comorbid, complicated stones and associated UTIs were excluded from the study. Patients were sorted into two groups of 35 patients, and were advised a combination of NSAID, an alpha blocker (either Tamsulosin or Silodosin) and an anti-inflammatory in form of serratiopeptidase. All patients were followed at 1 weekly by ultrasound and clinical assessment.

Results:

In the Tamsulosin Group, 28 (80%) were male while 7 (20%) were females. 22 patients took the medicine for less than a week and then either passed the stone or were surgically intervened. Total 19 (54.2%) patients passed the stone with the earliest on 3^rd day of medication. 23 patients had complete resolution of hydronephrosis. 16 (45.7%) Patients were surgically intervened with URS. Ureteral access was achieved in 10 patients, while 6 only underwent DJ stenting. 7 Patients achieved complete stone clearance while 1 could get partial clearance, 3 patients were pre stented. In Silodosin Group, 22 (62.8%) were males while 13 (37.1%) patients were females. 26 patients took the medicine for less than or till 7 days and then either passed the stone or were surgically intervened. Total 23 patients passed the stone, with the earliest on 3^rd day of medication. 12 (34.2%) Patients were surgically intervened with URS.

Conclusion:

Both drugs were comparable in terms of stone expulsion but Silodosin proved superior in relevance of earlier stone expulsion (p-value - 0.09)

Key words: Tamsolusin, Silodosin, Lower urinary Tract symptoms, Ureteric stone, METs