Background: Tele-practice is the application of telecommunication technologies in health and medical services. It facilitates cost-effective, quality, and flexible health and social services when the provider and the recipients are at a distance from each other.Objective: This research was designed to determine the knowledge of Tele-practice among health professionals working with Developmental Delayed Children. Methods: An Observational study conducted from August 2020 to July 2021 at the Department of Developmental Pediatrics Children's Hospital & the Institute of Child Health Lahore. Data was collected through consecutive sampling. The sample size was 100 and data was collected from both male and female Health Professionals who had working experience of a minimum of 2 years. Data analysis was done by using the IBM SPSS Statistics 25. Result: 34% of health professionals agreed that the use of tele-practice to provide services to developmentally delayed children is satisfactory. 20% of health professionals disagreed with the statement and 31 % were neutral about the statement. 34% of health professionals showed interest in the Future use of Tele-practice while working with developmentally delayed children and 28 % of health professionals showed no interest in the use of Tele-practice in future. Conclusion:  Most health professionals want the resources of tele practice must be encouraged so that adequate services would be provided to the people who come from remote and rural areas.                             Index Terms- Tele-rehabilitation, Developmental Delayed, children, Health professionals