Despite harmonious circumstances, a simple and effective approach for the synthesis of Schiff base metal complexes has been described. The necessity for creating innovative chemotherapeutic drugs with a wide range of biological activities and functions has been highlighted by the synthesis and characterization of physiologically active Schiff base metal complexes. The absence of solvents, catalysts, and complicated work-up conditions make this synthetic procedure appealing for obtaining unique physiologically active complex derivatives. The interaction between Schiff base metal complexes with different oxidation states has been comprehensively examined in this study, with a yield ranging from 69% to 80%. The produced compounds have been examined using FT-IR, 1HNMR, and 13CNMR spectroscopy methods. Using thrombolysis and hemolysis, the pharmacological properties of these compounds have been assessed. The potential of all the target compounds (10a-e) as thrombolytic and hemolytic agents is modest to medium. Compound 10c had the best thrombolytic capability and the least amount of cytotoxicity among the synthesised derivatives.

Keywords: Biomedical applications, cytotoxicity, hemolysis, metal complex, schiff base ligand (L), thrombolysis.