Coccinia grandis is a wild plant that is widely distributed in Vietnam, scattered throughout the provinces, especially the plains and high mountains. Not only is it a cooling and detoxifying food, it is also a traditional medicine with many uses such as anti-oxidation, anti-blood clotting, increasing insulin and preventing diabetes, anti-inflammatory, capable of protecting the liver and heart. This is a medicinal herb with a lot of potential, so the project "Investigating the antioxidant activity and in vitro sugar potential of ethanol extract from Coccinia grandis (L.) Voigt, Cucurbitaceae" was carried out. The results showed that the ethanol extract had a polyphenol content is 13.235 ± 0.32mg GAE/g extract and flavonoid is 11.125 ± 1.39mg QE/g extract. Antioxidant activity survey results show that ethanol extract has the strongest activity on ABTS^Ÿ+ (EC₅₀ = 361.26µg/mL), NO^Ÿ (EC₅₀ = 394.82µg/mL), DPPH (EC₅₀ = 482.42µg/mL), TAC (EC₅₀ = 657.52µg/mL), RP (EC₅₀ = 959.47µg/mL), and finally FRAP (EC₅₀ = 1231.33µg/mL). Coccinia grandis grown in Vietnam showed that the EC₅₀ value of α-amylase and α-glucosidase enzyme inhibitory activity was 517.927µg/mL and 479.570µg/mL.

Keyword: Antioxidant, Coccinia grandis, flavonoid, hypoglycemia, polyphenol.