Sindh Krait (Bungarus sindanus) is a highly venomous snake found in South Aisa that have critical threat due to unavailability of specific antivenom and low efficacy of commercially available antivenom against this deadly snake. This study reports the first holistic development of specific antivenom against Sindh Krait addressing the treatment gap for the envenomation of this snake. The venom was collected from Sindh Krait from the Sindh Province of Pakistan and traditional approach was used to develop antivenom in horses. Hyperimmune horse plasma was processed using caprylic acid and ammonium sulphate precipitation methods and the resulting antivenom was tested for its safety and efficacy. The results showed that the newly developed antivenom is highly effective against venom of Sindh Krait and hence provides a promising solution for improving the treatment of envenomation of Sindh Krait.

Index Terms- Antivenom, Envenomation, Neglected Tropical Disease, Sindh Krait, Snake, Snakebite, South Asia, Venom