The phenomenon of counterfeit drugs was widely discussed during the last decades. According to the World Health Organisation (WHO), counterfeit drugs are those that are knowingly mislabelled, and they may contain little or no active ingredient. Indeed, investigators have found toxic and fatal ingredients in some counterfeit drugs. The sale of these products is facilitated by the crypto market, and the products most traded are illicit opiates, stimulants, and prescription drugs. Consumers beside US dollars they use Bitcoin, a digital currency, to buy the products. Silk Road is a popular marketplace that was first discovered in 2011. Users access Silk Road using specialized TOR software. 

Objectives: The aim of this observational study is to find the relationship between the prices and weight in grams and strength of tablets in milligrams of the traded counterfeit/falsified prescription drugs in the Silk Road marketplace during a specific period. 

 Method and setting: The setting of the study was conducted in the dark web at the SilkRoad platform, to open the dark web the steps initially included downloading TOR software, this link was obtained from google. The second step was to create an anonymous account to login into the platform. Data collection was based on drug advertisements data gathered from the website in the period from the 9^th of June 2021 until the 24^th of June 2021 were analysed by SSP software. 

 Results: 168 advertisements were analysed in the study. Analysis of 39 cocaine advertisements results were 95% CI (9.95– 48.71) and p value< 0.001; heroine analysis includes 44 advertisements resulted in 95%CI (12.1 – 44.21) and p value< 0.001, both models were significant. While the other models their results were not significant and have some limitations. 

Conclusion: The final finding and results of the study indicate that there are a strong models to be studied and create good results and there are weak models that need further investigations.  

Key words: counterfeit drugs; falsified drugs; crypto market; Darknet; Silk Road; marketplace, vendors; dealers; consumers; opioids; stimulants; Benzodiazepines; cocaine; heroin; sildenafil.