Background: Chronic liver disease (CLD) is defined by damage to the liver parenchyma and its regeneration resulting in fibrosis and cirrhosis with progressive deterioration of liver functions. Von Willebrand factor (VWF) has recently been linked to the development and progression of liver illnesses including cirrhosis.Objective: to evaluate the level of (VWF) in patients with (CLD).Patients and Methods: A case - control study was carried out on 90 children. Have an age ranged between 8 months to 15 years old. Data was collected from children in addition to complete systematic physical examination including stigmata of (CLD) and complications of liver cirrhosis.Results: There was significant differences in VWF-Ag level between patients and control groups (P= 0.000) and also the level of VWF significance increase in patients with INR>1.1 (P= 0.005) and albumin<3.5 g/dl (P= 0.002) and There was positive correlation between VWF-Ag level and Pediatric End-Stage Liver Disease sore (P= 0.013) and child -Pugh score (P= 0.002).Conclusion: Level of VWF Ag can be used as a marker for increase severity of chronic liver disease taking in consideration child Pugh and PELD scores.

Keywords: Von Willebrand factor, chronic liver disease.