In the healthcare sector, the well-being of nurses is crucial not only for their satisfaction but also for the quality of care they provide. Burnout, a state of chronic stress and fatigue, can significantly impact nurses' job satisfaction and overall well-being. This, in turn, can affect patient safety and care quality, as stressed and dissatisfied nurses may have reduced effectiveness in delivering care. Objective: This study aims to evaluate burnout among nurses, job satisfaction, nurse well-being, and its influences on patient safety and quality of care.Methodology: An analytical cross-sectional study was conducted at a tertiary care hospital in Khyber-Pakhtunkhwa questionnaires were distributed manually among 120 nursing staff, and 75/120 willing to participate in data collection. Random sampling techniques were used. Results: A recent survey among nursing professionals has highlighted troubling levels of emotional exhaustion and depersonalization. (97.3%) admitted to feeling emotionally drained by their work. (95.5%) felt used up by the end of the day. (91%) felt fatigued when starting a new workday, and almost nine out of ten (89.3%) struggled with the strain of working with people. A notable proportion (54.6%) reported effectively managing their clients' issues, suggesting a sense of personal accomplishment. Conclusions: The study indicates a need for interventions to address the challenges faced by nursing staff in tertiary care hospitals. Strategies such as bolstering support, optimizing staffing, and addressing issues like bullying are crucial to improving patient care and staff well-being.

Key words: Nursing; Stress; Burnout; Emotional exhaustion; Depersonalization; Personal accomplishment, patient safety, job satisfaction; Workload; Healthcare management.