It is advantageous to apply ethnobotanical and phytochemical research in the search for new drugs. One crucial step in identifying the bioactive components of curative plants used in conventional therapy is screening for phytochemicals. 12 curative plants used in traditional Mir Ali subdivision North Waziristan Pakistan medicine were investigated for the first time. The period of ethnobotanical fieldwork was 2017-2019. Several curative plant species were found and categorized into relevant families. These curative plants were screened using standard protocols to look for the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, phenol, phlobatannis, saponins, steroid, tannins, terpenoids and triterpenes. It has been demonstrated that the leaves of all 12 plant species (100%) contained triterpenes, 11 plant species each (91.7%) contained steroid, tannins, flavonoids 10 plant species (83.3%) contained Saponins, 8 plant species each (66.7%) contained Alkaloids, Cardiac glycosides, Phenol and Terpenoide, while 7 plant species each (58.3%) contained Carbohydrates and phlobatannis were the most often used phytochemicals among the curative plants. It has been demonstrated that the leaves of all 12 plant species i.e., Fagonia indica Burm. F., Withania coagulans (Stocks) Dunal, Datura stramonium L., Olea ferruginea Wall. ex Aitch, Nerium oleander Mill., Tribulus terrestris L., Mentha longifolia L., Lepidium draba L., Trachyspermum ammi L., Verbascum thapsus L., Rhazya stricta L., Justicia adhatoda L. contain Triterpenes. The presence of Triterpenes in these curative plants is congruent with their anthropological significance.

Key words: Phytochemicals, curative plants, alkaloids, carbohydrates, cardiac glycosides, flavonoids, phenol, phlobatannis, saponins, steroid, tannins, terpenoids, triterpenes, Mir Ali Subdivision, North Waziristan.