Viral outbreaks are a common cause of morbidity and mortality in livestock and human populations. Lack of good vaccines and poor control measures along with natural viral genetic drifting and shifting are the common causes of new viral strains and outbreaks. The current study reports the synthesis of a series of chalcones derivatives of 5-Arylfuran-2-carbaldehydes. Two important poultry viruses: Avian influenza virus (AIV; A/Chicken/Italy/1994/H9N2) and infectious bronchitis virus (IBV) were selected, grown in 9-11 days old chicken embryonated eggs, and subjected to in ovo anti-viral assays. Most of the synthesized compounds were found active against AIV subtype H9N2 and IBV. In the case of AIV, the best results were attained for compound 3,4,6,10,12,13,17 and they retained HA titers at 0 after challenge. The lower titer values of these compounds showed high potency of these compounds, especially in comparison with control groups.The next in order was compound 9 which kept HA titers value at 2. While other compounds were found less effective than above mentioned compounds and they kept the HA titers at 8, 16, 32, 128 and 2048 respectively. While in case of IBV, compound 5,9,13 and 16 found to be more effective and showed titer value zero. While other compounds showed moderate activity against IBV. The standard drugs amantadine and ribavarin were used as positive controls in the case of AIV and IBV, respectively.

Keywords;5-Arylfuran-2-carbaldehyde, Chalcones, Antiviral activity, Antiviral inhibitors etc.