Mycobacterium tuberculosis is a slow-growing facultative intracellular parasite, which is common cause of infectious diseases in developing countries. It is still a major health issue in the rural and urban areas of Pakistan. The current study was conducted to assess the frequency of tuberculosis (TB) with relation to socio-demographic profile of the patients in local population of District Bajaur, Khyber Pakhtoon Khwa, Pakistan. A cross-sectional study was conducted in District Headquarter Hospital (DHQ) Khar Bajaur, Khyber Pakhtunkhwa, Pakistan, from 31^st December, 2020 to 23^rd June, 2021.  A structured and close-ended questionnaire was used to collect data about sociodemographic profile of the patients infected with Mycobacterium tuberculosis, at TB control center of DHQ Khar Bajaur and data were analyzed using statistix9 and Microsoft excel. The number of studied patients was 200, out of which (45.5%) were female and (54.5%) were male. The highest number of patients among males (41.5%) were belonged to the age group 31-40 years, while the lowest in male (1.83%) were in age group 61-70 years. The highest number of patients among gender female (32.96%) were fall in age group 21-30 years, while the lowest in female (3.29%) were fall in age group 1-10 years.  The distribution of male patients was 18.34%, found in Tehsil Nawagai and lowest were 11.92% in Tehsil Chamarkand. On the other hand, female patients were 24.18%, belonged Tehsil Utman khel and 7.69% belonged to Tehsil Mamund.  The most frequent type of TB was pulmonary tuberculosis (110/200), on contrary bone TB was least common among the patients of this geographical areas. Majority of the patients were with low socio-economic status (110/200). It was concluded that Pulmonary TB is the most common disease in the rural communities in Khar Bajaur, and high incidence was recorded in male as compared to female. Socio-economic status is the major cause of tuberculosis among the local population of District Bajaur.

Keywords: Mycobacterium Tuberculosis, Tuberculosis, Socio-economic status, Risk Factors, Tehsils.