The purpose of this qualitative research design study was to determine the difficulties faced by nurses who provide care for patients with COVID-19 diagnoses. The study's population consisted of the nurses working one-on-one with COVID-19 patients in different tertiary care hospitals south Punjab Pakistan. The sample for the study was chosen using the greatest variation sampling technique. Hospitals were chosen at random for the sample selection process. The study's sample comprised fifteen nurses who provided one-on-one care to patients diagnosed with COVID-19 during April and May 2020, worked in several hospitals across Punjab, chose to take part in the study, and consented to be interviewed by the researcher. The study was reported in accordance with SRQR criteria. Seven challenges, or seven themes, were found as a result of the investigation. Anxiety and worry of contracting the disease, alterations to the family hierarchy, providing medical care when afraid, Social stigma, Challenging the position of the nurse in the healthcare system, working with personal protection equipment being difficult and  physical harm brought on by the apparatus are some of these themes.

Index Terms- difficulties faced by nurses, COVID-19, nursing care, and qualitative research