Objective:

The objective of this study was to assess the distribution of Child-Pugh scores among a cohort of CLD patients and to estimate liver enzymes in these patients.

Materials and Methods:

This was a descriptive cross sectional study carried out in Jinnah post graduate medical center Karachi, Pakistan. A total of 200 subjects were recruited in the study after applying inclusion and exclusion criteria. The subjects were divided into four groups: control group, group A, group B and group C according to Child Pugh Score. Written informed consent was obtained from all participants. The data obtained was stored and analyzed using SPSS Version 23.

Results:

Significant differences were observed in Total Serum Bilirubin, Albumin, INR, Alkaline Phosphatase (ALP), Aspartate Transaminase (AST), Alanine Transaminase (ALT), across these groups. Total Serum Bilirubin, INR increased, while Albumin decreased with worsening liver disease. ALP, AST, and ALT levels showed an increase with advancing Child-Pugh scores.

Conclusion:

The study revealed substantial variations in liver-related biochemical parameters across the control group and different Child-Pugh score groups, indicating the impact of liver disease severity on these markers. These findings contribute to a better understanding of the biochemical profile in CLD patients and can aid in refining clinical assessments and treatment strategies for patients with varying degrees of liver disease.

Keywords: Chronic Liver Disease, Child Pugh Score, Liver Enzymes