Background: - The transradial approach is recommended for percutaneous coronary intervention (PCI) due to decreased associated complications. Safety nursing measures involved in transradial PCI are critical for better outcomes. Aim: -This study aimed to determine the efficacy of implementing safety-nursing measures on clinical outcomes of patients undergoing emergency transradial percutaneous coronary intervention. Design: - Quasi-experimental research design. Setting: - This study conducted in coronary care unit at Tanta Main University Hospital. Subjects: - Convenience sample of 60 adult patients undergoing transradial PCI divided into two equal groups, control group received routine care by coronary nursing staff and study group managed by safety nursing measures that implemented by the researcher. Tools: -Two tools had been used. Tool I: Structured interview schedule. Tool II. Transradial percutaneous coronary intervention: clinical outcomes assessment tool. Results:  There was significant difference between both groups in relation to bleeding, hematoma, neurovascular complications and wrist pain but it was not significant in relation to hand ischemia and compartment syndrome. Conclusions:  Safety nursing measures which included safety measures before, during the procedure and safety measures after the procedure that consisted of continuous monitoring of hemodynamic parameters, cold application around insertion site, blood pressure cuff inflation, interventional limb raising management strategy and velpeau bandage had a positive effect on patients' clinical outcomes. Recommendations: - Safety nursing measures should be carried out as a routine care for patients undergoing emergency transradial PCI.       

 Key words: Safety nursing measures, Emergency transradial PCI, Clinical outcomes