The aim of present study is to evaluate the anti-convulsion, analgesic and anti-inflammatory effect of Lagenaria siceraria and carbamezapine. Lagenaria siceraria as a medicinal plant, its fresh juice have not been examined for its activity till date. Due to the side effects of carbamezapine, have been used to evaluate its anti-convulsion, analgesic and anti-inflammatory effect in comparion through oral route. Anti-convulsion activity were performed by inducing convulsion with pilocarpine 2%, analgesic and inflammatory activities were studied by means of acetic acid induced writhing test and formalin test respectively. Treated animals received oral dosage of L. siceraria (400mg/kg) and carbamezapine (6mg/Kg). Anti convulsant results showed that L. siceraria did not protect convulsion but it produced delayed tremors. Analgesic activity showed that CBZ and L. siceraria produced significant reduction in pain in comparison with the standard drug (aspirin). L. siceraria produced 87.5% and 83.3% reduction of pain in writhing test. It also exhibited significant analgesic activity in formalin induced licking and biting test. CBZ produced 87.5 % analgesic effect in peripheral phase and 100% in neurogenic phase in writhing test, while in licking and biting test CBZ also reduced pain (58.6% and 74.1% respectively in first and second phase). In Combination group pain reduction response was increased which reflected the significance of both drugs as an analgesic agent. CBZ and Lagenaria siceraria both reduced inflammation in formalin induced hind paw edema. The reduction of inflammation with L. siceraria decrease upto 44.8% and 64.5% in both phase. CBZ decrease 58.6% phase 1 and 74% respectively with phase 1 and 2. Whereas, the combination group markedly reduced inflammation with synergistic effect.

Conclusion: Lagenaria siceraria fresh juice delayed the symptoms of convulsion and produce significant analgesic and anti-inflammatory effect through oral route, in combination with carbamezapine

Keywords

Lagenaria siceraria, anti-convulsion, analgesic, anti-inflammatory, carbamezapine