Therapeutic plant preparations may contain critical levels of poisonous substance constituents to possibly make genuine damage to animals as well as people. Accordingly, toxicity examines are significant to possibly make toxic impacts of plant derived products. Natural medications from therapeutic plants are seen as a powerful and safe discretionary treatment for liver injury. The acute toxicity study demonstrated that the aqueous extract of Polygonum Persicaria is harmless even at the highest dosage of 2000 mg/kg in albino Wistar rats. There were no behavioural or physiological changes and gross pathological irregularities watched. The toxicity examination of aqueous extract of Polygonum Persicaria at 5, 50, 300, and 2000 mg/ kg were led in albino Wistar rats. The current examination was directed to evaluate the hepatoprotective association of aqueous extract of basic roots of Polygonum Persicaria at an oral dosage of 200 and 400 mg/kg in wistar rats. The investigations were coordinated with the prompting specialist CCl₄ (1.5 ml/kg i.p). Silymarin (100) mg/kg p.o) was used as a kind of perspective cure in particular models. The effect was tested by enzymatic level assessments and histopathological examinations. Polygonum Persicaria aqueous extract has demonstrated significant hepatoprotection against CCl₄ induced hepatotoxicity study models in wistar rats. This has been illustrated by a pronounced reduction in serum marker proteins. The protecting ability of Polygonum Persicaria against hepatoprotective stimuli may be due to the phenolic or flavonoid compounds that we have found through phytochemical analysis. The hepatoprotective design of the extract was also affirmed by histopathological tests.

Keywords: Carbon tetrachloride, acute toxicity, hepatoprotective, Polygonum Persicaria, Silymarin, Histopathology.