Introduction:

Hyperlipidemia, characterized by elevated cholesterol and triglyceride levels, poses a significant health risk, necessitating effective interventions. This study explores the potential of Moringa oleifera, a natural plant product rich in nutrients, as a promising candidate for regulating lipid profiles. Moringa oleifera has gained recognition for its diverse health benefits, making it an intriguing subject for managing hyperlipidemia.

Methodology:

Conducted at the Pharmacology department, University of Karachi, the study involved eighteen male Wistar rats distributed into three groups: a control group, a hyperlipidemic group treated with Moringa oleifera, and a hyperlipidemic group treated with the standard drug, Atorvastatin. Hyperlipidemia was induced through subcutaneous Dexamethasone injection for seven days. Blood samples confirmed hyperlipidemia, and subsequent treatment with Moringa oleifera leaf extract (0.06 mg) and Atorvastatin (0.6 mg) was administered for 21 days. Statistical analysis using SPSS 20 assessed lipid levels.

Results:

Both Moringa oleifera and Atorvastatin demonstrated significant reductions in total cholesterol, triglycerides, and LDL-C levels. Additionally, positive trends were observed in HDL-C levels. Statistical analysis revealed noteworthy changes in lipid levels from Day 0 to Day 21 in both treatment groups.

Conclusion:

The research highlights that Moringa oleifera proves to be a healthy and cost effective natural substitute to Atorvastatin, a standard hypolipidemia

Keywords: Hyperlipidemia, Moringa Oleifera, Atorvastatin