Objective: To evaluate the influence of ketogenic mediterranean with phytoextracts diet on hyperandrogenism markers in married women with polycystic ovarian syndrome. Methodology: A Randomized control trial (pre- post treatment) was conducted among 47 participants with BMI 25.0 – 29.9 and who meet the inclusion criteria. The participants were selected from Mansoora Hospital Gynecology OPD, Lahore. All the participants were advised to take ketogenic mediterranean with phytoextracts diet which is very low caloric ketogenic diet (1000kcal) + phytoextracts for first 3 weeks, low caloric ketogenic diet (1200kcal) + phytoextracts for second 3 weeks and Mediterranean diet (1600kcal) + phytoextracts for last 6 weeks. It was requested that the participants refrain from using any additional dietary supplements. The lab test for hormones LH, FSH and total cholesterol, LDL, HDL and triglycerides levels were collected on 0 week and after 12th week of study. Followup was taken on 0 week and 12^th week of both groups. Results: Average mean age of participants is 29.30. The mean difference of BMI pre and post treatment is 28.78±1.17 to 25.82±1.25. The mean difference of LDL in pretreatment 123.70±12.94 to post treatment 91.53±3.38 mg/dl and total Cholesterol level pretreatment 206.26±9.26 to post treatment 184.81±7.90, HDL pretreatment 72.55±9.68 to post treatment 82.00±8.19 and triglycerides level pretreatment 204.32±22.56 to post treatment 169.57±12.13 was observed. The difference of hormones level (FSH, LH and LH:FSH) were also observed. The mean difference of hormones in LH pre and post treatment (10.54±0.52 to 6.80±0.51), FSH pre and post treatment (5.18±0.20 to 5.57±0.18), LH:FSH pre and post treatment was (2.03±0.12 to 1.22±0.10). Blood glucose levels (91.51±3.20 to 82.43±2.33), body fat percentage (27.06±3.26 to 19.89±2.39), and ferriman-gallwey score (15.13±2.53 to 14.45±2.38). also presented some reduction. Conclusion: ketogenic mediterranean with phytoextracts diet showed significant reduction of BMI in overweight participants (p<0.05). A significant reduction in LDL, HDL, total cholesterol, triglycerides and LH were also observed. So, Null hypothesis is rejected and the alternative hypothesis is accepted i.e, ketogenic mediterranean with phytoextracts diet has effect on hyperandrogenism markers among married women with polycystic ovarian syndrome.

Key words: Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Hyperandrogenism, Insulin resistance, Hypercholesterolemia, Ferriman-Gallwey score.