- The research conducted in this study focused on the use of pure drugs, namely artemether and/or lumefantrine, both individually and in combination with proposed excipients. These excipients included avicel-102 (microcrystalline cellulose), primojel (starch glycolate sodium), aerosil (colloidal silicone dioxide), and magnesium stearate.

The investigation also involved assessing the inactive ingredients, including lubricating agents and diluents, both separately and in combination, to determine their physical and chemical compatibility. Various physicochemical tests were performed, such as measuring diameter, thickness, hardness, disintegration, friability, and percentage purity.

Samples of the formulations were placed under accelerated stability conditions, which included a temperature of 40±2 °C and humidity of 75±5% RH, to assess their stability. Differential scanning calorimetry (DSC), high-performance liquid chromatography (HPLC), and Fourier transform infrared spectroscopy (FTIR) were used to further evaluate chemical compatibility.

The final finding of this study was that the inactive substances utilized in the formulations did not interact in any way, either physically or chemically, with the active medication components.

Index Terms- artemether, differential scanning calorimetry, lumefantrine, primojel,