Leaf rust disease, caused by Puccinia triticina, is a major threat to wheat production in Pakistan, reducing the yield by up to 10% compared to other rust types such as stem and yellow rust. The disease severity varies depending on the plant's growth stage and susceptibility. Wheat is the most important and nutritious crop in Pakistan, due to its diverse growing conditions, climatic patterns and genomic features. The most effective and economical way to manage this disease is to breed resistant varieties. However, this is an ongoing process, as the pathogen can mutate and overcome the resistance of any variety. The experiment conducted in wheat research institute, Faisalabad, 250 wheat genotypes including commercial varieties, newly developed lines and land races were screened for brown rust consecutively in three years 2019-2020, 2020–21, and 2021–22, three varieties Arooj 2022, NARC Super 21, Dilkash 20 were symptomless and indicated high grain yield per plant. After comparing varieties, showing resistance against disease in the last three years While Pakistan-81 and Galaxy 13 were susceptible throughout this period. Moreover, after comparing environmental conditions favoring disease development in last three years it was observed that low temperature from 17 to 22℃,  humidity  above  80%  and  high  rainfall  increases  the  incidence  of  disease development.

  keywords: wheat, brown rust, environment