The prevalence of neurodegenerative ailments like Parkinson disease is spreading all around the globe is posing threat and an alarming situation for human society. Cyanidin-3-glucoside being a marvelous polyphenolic candidate who has earned its fame of having multi properties like antioxidant, antitumor, anti-inflammatory and neuro protective as well. According to considerations about pathogenesis of Parkinson disease, mitochondrial dysfunction and oxidative stress is involved in Calcium homeostasis and Calcium channels regulation but exact mechanism related to Calcium channel is not clear. Cyanidin-3-glucoside has been proved itself as a very potent player of performing its activities in maintaining Calcium homeostasis by decreasing oxidative stress, by waning reactive oxygen species and by preventing Calcium⁺induced mitochondrial depolarization. Studies have been done on different models of Parkinson disease on different aspects but effect of C3G to prevent neuronal loss through Calcium⁺ channels in PD is still hidden.

Key words

Cyanidin-3-glucoside, Parkinson disease, Ca²⁺ channels