Pyrimidine derivatives are known as essential pharmacophores in the field of medicine. Owing to their remarkable activities, we synthesize a series of compounds having pyrimidine moiety. First of all we prepared two acetyl derivatives of thiopyrimidine (5 and 6), then they react with different Aryl aldehydes to form various chalcones .The synthesized compounds were characterized by different analytical techniques and screened for their antidiabetic activity. Almost all synthesized compounds showed good to excellent antidiabetic activity.

Keywords; 5-Arylfuran-2-carbaldehyde, Chalcones, Antidiabetic activity, pyrimidine derivative, Claisen Schmidt condensation etc.