To evaluate the difference in the effect of Lutein-Zeaxanthin, and Omega-3 oral supplements on evaporative dry eye. And assessing the acceptability rate of patient with oral supplements and artificial tears eye drop for the management of evaporative dry eye.A Quasi-Experimental study was conducted at the Department of Ophthalmology in DG Eye Care Hospital, Dera Ghazi Khan from September 2022 to May 2023. The sample size was calculated using a Rao-soft sample calculator by estimating the prevalence rate with a confidence interval of 95% and a margin of error of 5%. A total of 90 patients were selected. Data was collected in a questionnaire format and analyzed through SPSS software version 23. Out of 90 patients, Group 1 (Omega-3 oral supplement) had a mean value and standard deviation of n 11.17+.874, group 2 lutein-zeaxanthin oral supplement had a mean value and standard deviation of 9.53+.730 and group 3 artificial tears eye drop had a mean value of 10.57+.165. The overall results showed that a significant difference of p=0.00 (p<0.05) was present between the omega-3 oral supplement with the lutein-zeaxanthin oral supplement and artificial tears eye Drop, with a slightly significant value of p=0.046 (p<0.05). The lutein-zeaxanthin oral supplement showed a significant difference of p=0.000 and p=0.000 with other treatments. Meanwhile, the artificial tears eye drop showed a difference of p=0.046 (p<0.05) with the omega-3 oral supplement. The overall results showed that a significant difference of p=0.00 (p<0.05) was present. The study showed omega-3 was more effective, and artificial tear eye drops had a minimal difference in effectiveness compared to omega-3 fatty acids, which showed remarkable potential in decreasing the symptoms associated with dry eye.

Index Terms- Dry Eye, Lutein-Zeaxanthin, Omega-3, tears Eye Drop