OBJECTIVE: The objective of the study was to compare mean blood loss with and without topical tranexamic acid in patients undergoing coronary artery bypass grafting.

METHODS: It was a randomized controlled trial, conducted at Shaikha Fatima Institute of Nursing and Health Sciences Lahore between May to December 2022. Total 130 patients who underwent coronary artery bypass grafting were included in the study. Randomization was done by assigning even numbers to intervention group and odd numbers to placebo group. A proforma was filled containing demographic information of the participants and blood loss during surgery and transfusion of any blood product. The data was entered and analyzed using the SPSS v25.0.

RESULTS: Total 130 patients undergoing coronary artery bypass grafting were studied. Blood loss in each group was measured in milliliters, in intervention group mean blood loss was 366.52ml with a standard deviation of 32.38 and in placebo group mean blood loss was 483.08 with 86.26 standard deviation, difference between the mean blood loss among  groups was statistically significant with  p-value=0.001 by applying t-test.

CONCLUSION: Patients having primary coronary artery bypass grafting lead to a substantial decrease in post-operative blood loss and the need for blood transfusion when tranexamic acid (TXA) was applied topically.

KEYWORDS: Coronary Artery Bypass Grafting, Blood Loss, Tranexamic Acid.