Introduction: Psoriasis is an immune-mediated illness with an unknown etiology, defined by inflammation induced by immune system malfunction, which leads to inflammation in the body. Objectives:  The aim was to the assessment levels for (IL-17 and IL-22) and their correlation with psoriasis.

Patients and Methods: About 25 psoriatic patients and 25 healthy people had their blood samples (3 ml) taken. For at least one month prior to the Interleukin evaluation and sample collection during the period from January to May 2022, all patients included in this study had no systemic treatment, and patients and healthy volunteers gave their informed consent. Follow the manufacturer's instructions to determine serum IL-17 and IL-22 levels using sandwich ELISA kits.

Results:  Results of current study showed male 56% (No =14) were more than female44% (No = No ==11) female. Also, the age was (41≤ years) more infected at 44%( No =11), Followed by the age group (21-40) years at 36% (No.=9) compare to the control. as well as the mean concentration of IL-17 in psoriatic patients was (4.49± 3.70) pg/ml, while concentration of IL-17 was (3.00 1.21) pg/ml in controls. In comparison to the levels of IL-22 in the Control (healthy person) (23.01± 0.45), psoriatic patients' sera showed a higher level (45.29± 0.12).

Conclusion: Male were infected with psoriasis more than Females, with age (41≤ years) and (21-40) years, so psoriatic patients' sera showed higher levels of both interleukins (IL-17 & IL-22), and found a relationship between psoriasis and both interleukins (IL-17 & IL-22).

Keywords: Interleukins; biomarker; psoriatic Iraqi patients.