Diabetes Mellitus is a serious health problem and is characterized by hyperglycemia, caused by the low level of insulin or its abnormal functions. Among various measures to control diabetes, medicinal plants, showing anti-diabetic activity are in great concern to control blood glucose level. Anti-diabetic and hypolipidemic effects of Momordica charantia and Azadirachta indica extracts was evaluated in the streptozotocin-induced diabetic male albino rats. Total 30 male Wistar rats were divided randomly into 5 treatment groups (n=6). Diabetes was induced in rats using single dose of Streptozotocin (55mg/kg). Group A was treated as normal and group B was treated as diabetic control. Group C and D were given an extract of M. charantia and A. indica respectively (100mg/kg BW), whereas, group E was treated with extract of both plants. After 21 days blood samples were collected for the biochemical analysis. The treatment with both plants extracts showed a significant (p<0.05) reduction in glucose level and body weight of rats. Similarly, Level of cholesterol, low-density lipoprotein, triglycerides, and very low-density lipoproteins were decreased, whereas, high-density lipoprotein was increased significantly (p<0.05) in rats of group E. Extract of both plants showed an effective anti-diabetic and hypolipidemic effects on diabetic rats. A combination of both Momordica charantia and Azadirachta indica extract can be used for the management of diabetes.

Index Terms: Diabetes mellitus, Momordica charantia, Azadirachta indica, Anti-diabetic, hypolipidemic