Background: Syzygium aromaticum (clove) has a conventional therapeutic anti-inflammatory use. Cold ethanolic extraction of Syzygium aromaticum was aimed to investigate the anti-inflammatory activity in animal model. In vivo inflammation was observed by carrageenan. Anti-inflammatory activity of Syzygium aromaticum was tested & compared with standard (ibuprofen 10mg/kg).

Objective: The objective of this study is to evaluate the anti-inflammatory effect of Syzygium aromaticum extract on carrageenan induced paw edema in mice.

Method: The anti-inflammatory potential of drug was tested in mice. A combination of drug was set as high dose & low dose with standard. Animals were divided into 6 groups each containing 2mice. Group 1 was administered normal saline considering it as controlled. Remaining groups were administered standard (ibuprofen), low dose extract of Syzygium aromaticum , high dose extract of Syzygium aromaticum , combination of low dose extract with standard & combination of high dose extract with standard to groups II, III, IV, V, VI respectively.

Results: The effect of ethanol extract of Syzygium aromaticum as anti-inflammatory was evaluated. Extracts having two different strengths i.e., 250mg/kg (low dose) & 500 mg/kg (high dose) were used for study which produced significant effect against carrageenan induced paw edema. Distinctively, combination of high dose with standard & low dose syzygium aromatic gave best anti-inflammatory effect.

Conclusion: The effective results of Syzygium aromaticum substantiate its traditional use as anti-inflammatory agent.

Keywords: Syzygium aromaticum, clove extract, carrageenan, anti-inflammatory.