The ethanolic leaves extract of Allium Cepa with its increasing dosages, that is, 200 mg/kg, 250 mg/kg and 300 mg/kg were used to determine the antidiabetic activity in rats in which diabetes was induced by using alloxan monohydrate for 2 weeks at the dose of 150 mg/kg. The results were compared to the increasing dosages of standard antidiabetic drug glibenclamide at the dose of 2.5 mg/kg, 3.8 mg/kg and 5 mg/kg respectively and also against the control, that is, normal saline. It was observed that with the increasing dosages (200 mg/kg, 250 mg/kg and 300 mg/kg) of ethanolic leaves extract of ALLI given to rats, it produced dose dependent significant (that is, p < 0.05) reductions in the blood glucose levels of diabetic rats after a treatment of 6 weeks in comparison to the control rats that received normal saline. The most effective concentration at which there was significant blood glucose level reduction seen was at the dose of 300 mg/kg. Hence, from this experiment, it is evident to conclude that Allium Cepa has the ability to exhibit promising hypoglycemic activity.

Keywords: Allium cepa, hypoglycemia, antidiabetic activity, alloxan, ethanolic leaves extract.