Previous studies have been demonstrated that high intimidate homeostatic and implies unfavorable mood changes, certain or intense feeling of dejection, oppressed. Unhappiness, despondency and down-hearted. The chronic stress leads to depression like symptoms. Due to the difference in steroidal level, women are more prone to stress than female. The objective of the study was to determine the impact of ferulic acid on behavioral and learning memory deficits in male rats induced by chronic unpredictable mild stress.

METHODS

In this present study twenty four animals we were randomly divided into two equal groups (i) Unstressed and (ii) CUMS. Animals of both groups were further divided into two groups (i) Unstressed-Water (ii) Unstressed- Ferulic Acid (10 mg/kg/day), (iv) CUMS-Water (v) and CUMS-Ferulic Acid (10 mg/kg/day). Animals of the CUMS group were exposed to a schedule of chronic mild stress shown in table over a period of 14 days, while animals of unstressed groups remained in their home cages. Water or respective dose of ferulic acid (10 mg/kg/day) was given orally to animals each day 1 hr before exposing to daily schedule of CUMS as shown in table. Food intake and body weight changes were monitored on next day of the 1st, 7^th and 14^th stress. Locomotor activities were monitored in familiar environment (activity box) and novel environment (open field) on next day of 1^st, 7^th and last stress.

RESULTS

Results from this study revealed that Ferulic acid is a potent antidepressants it shows positive behavioral effects in all three tests.

CONCLUSION

Present study concluded that the flavonoids like ferulic acids and others can be used as potent antidepressant and in order to improved learning and memory ability in rat model of CUMS induced depressive like behavior models

Key Words: Chronic unpredictable mild stress, depression, learning and memory deficits, ferulic acids, exploratory activity