Mangifera indica, commonly called the mango, is a tropical fruit tree that belongs to the Anacardiaceae family. Different parts of the plant have been utilized traditionally for various therapeutic purposes. The study intended to explore the diuretic impact of Mangifera indica fruit extracted in ethanol. The ethanol-extracted fruit of Mangifera indica was produced by maceration. The doses of extract selected by going through an extensive literature review are 100 mg/kg, 200 mg/kg, and 400 mg/kg. The diuretic activity was determined by comparing urine volume and urinary electrolyte excretion. The findings showed that the ethanolic extract of Mangifera indica fruit had a dose-related diuretic effect. The maximum diuretic effect was witnessed at a dose of 400 mg/kg, resulting in a noteworthy improvement in urine and electrolyte output in contrast to the standard control group (furosemide). The extract also showed a significant increase in potassium excretion, suggesting a potassium-sparing diuretic effect. Finally, the ethanolic extract of Mangifera indica fruit has a mild to moderate diuretic effect. Further research is required to explain the mechanisms of action and to identify the responsible active ingredients for the observed activities.

Keywords: Mangifera Indica, Furosemide, Diuretic Activity,