Background: Paracetamol is used abundantly as an anti-pyretic and analgesic drug. As this drug has beneficial effects, it is also the major reason of liver problems in humans as well as in animals used in the experiments.

Objective: The objective of this study was to evaluate the hepatoprotective effect of Moringa oleifera and Curcuma longa and to provide the knowledge of Moringa oleifera and Curcuma longa as hepatoprotective so people may use herbal drug despite synthetic medicine to treat hepatic diseases.

Methodology: Hepatotoxicity was induced by giving a single oral dose of paracetamol (3g/kg). To assess the hepatoprotective effect for 14tract of Moringa oleifera leaves (125mg, 250mg, & 500mg/kg) and extract of Curcuma longa rhizomes (125mg, 250mg, & 500mg/kg) or Silymarin (200mg/kg) was orally administered, for 14 days.

Results and Discussion: Paracetamol significantly raised the level of serum ALP, ALT, AST, and serum bilirubin. Oral dose of Moringa oleifera and Curcuma longa extract reversed paracetamol – induced hepatotoxicity and reduce the level of all the liver enzymes because both plants have antioxidant activity, which helps to reduce the oxidative stress and showed are markable hepatoprotective effect which prevents the harmful cascade of event induced by Paracetamol. Results of present study showed hepatoprotective effect of Moringa oleifera extract is better than the Curcuma longa extract.

Conclusion: Treatment with Moringa oleifera leaves extract and Curcuma longa rhizomes extract reduced raised level of ALP, ALT, AST, and Serum bilirubin because of its antioxidant activity and therefore both drugs have hepatoprotective effect but Moringa oleifera has better hepatoprotective effect that is why it should be preferred.

Keywords: Hepatoprotective effect, Moringa oleifera, Curcuma longa, Paracetamol