Purpose: The aim of this study was to find out the impact of phacoemulsification on IOP in subjects with and without pseudoexfoliation.

Method: A prospective longitudinal study design was conducted at Munawar Memorial Hospital & college of optometry chakwal. A convenient sample of 100 subjects with age 40 to 65 years old with best corrected visual acuity of <6/12 were recruited. Subjects were divided into two groups based on presence and absence of PXF. A baseline IOP of all subjects was measure by Goldmann Applanation Tonometer. All subjects underwent cataract surgery by phacoemulsification. After surgery, subjects were follow up and after 1^st and 6^th week, IOP rechecked in both groups. The baseline IOP values of both groups were compare with 1^st and 6^th week IOP postoperative value.

Results: The mean difference between baseline and 1^st week post operated IOP of PXF group was 2.120+0.849 and 1.600+1.355 in control group with p value < 0.05. The mean difference between baseline and 6th week post operated IOP of PXF group was 2.620+2.125 and 2.460+1.265 in control group with p value < 0.05. The comparative analysis between two groups showed that the mean difference between baseline IOP of PXF and control group was 1.360+3.832 with p value 0.015. Similarly, the mean difference of IOP of 6th week post-operative IOP between PXF and control group was 1.200+0.444 with p value 0.009, which was less than 0.05 with CI of 95%.   

Conclusion: Patients with PXF exhibited a more reduction in IOP after phacoemulsification as compared to controls. Higher preoperative IOP were associated with more IOP reduction which was found in PXF group.

Key words: Pseudo exfoliation, intraocular pressure, Phacoemulsification